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Bone

Dietary Intake of Flaxseed Oil since Early Stages of Life Promotes Femur Quality in Male Rats.

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Plasma phospholipid fatty acids, bone mineral density and fracture risk: Evidence from a Mendelian randomization study

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The Role of Omega-3 Polyunsaturated Fatty Acids from Different Sources in Bone Development

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Effect of hydroalcoholic extract of flaxseed on bone mineral density in Wistar rats using digital radiography.

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Diet is one of the risk factors for osteoporosis in addition to heredity, age, oestrogen deficiency, and calcium and phosphorus metabolism. Whether FO has a protective effect on HFD-induced bone damage has not been clarified, and the specific mechanism of bone protection is unclear. Therefore, this study aimed to evaluate whether totally replacing soybean oil and partly replacing lard with FO in HFD can improve high-fat-induced bone damage in vivo. We treated rat primary OBs with ALA in vitro to observe the effect of ALA on osteoblastic function, osteogenic-related gene and protein expression and tried to explore the mechanism of ALA on bone protection. The major finding of this study was that FO alleviated bone loss in HFD rats. Meanwhile, ALA can promote primary osteoblastic function through increasing β-catenin/RUNX2/osterix genes and proteins expression and restoring PA induced ALP activity decreases. The current study also focused on male rats, and trabecular bone loss was observed in HFD induced male SD rats. The bone loss induced by HFD was attenuated by treatment with FO, as shown by micro-CT, three-point bending test and bone histology analysis. The results showed that ALA dramatically promoted β-catenin gene and protein expression in OBs, which suggested that ALA may promote osteogenic differentiation through the Wnt pathway. In the present study, the main finding was that FO alleviated bone loss in HFD rats, probably by promoting osteoblastic β-catenin/RUNX2/osterix gene and protein expression and restoring PA-induced ALP activity decreases. These findings indicated that FO might be a potential therapeutic agent for HFD-induced bone loss, most likely by promoting osteogenesis.

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Cyclolinopeptide F, a cyclic peptide from flaxseed inhibited RANKL-induced osteoclastogenesis via downergulation of RANK expression.

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The Relationship Between Omega-3, Omega-6 and Total Polyunsaturated Fat and Musculoskeletal Health and Functional Status in Adults: A Systematic Review and Meta-analysis of RCTs.

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Lifelong intake of flaxseed or menhaden oil to provide varying n-6 to n-3 PUFA ratios modulate bone microarchitecture during growth, but not after OVX in Sprague-Dawley rats.

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Effect of Altering Dietary n-6:n-3 Polyunsaturated Fatty Acid Ratio with Plant and Marine-Based Supplement on Biomarkers of Bone Turnover in Healthy Adults.

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Incorporation of Flaxseed Flour as a Dietary Source for ALA Increases Bone Density and Strength in Post-Partum Female Rats.

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Most Recent Flax Research Articles

  • Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition.
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    Research studies on flaxseed have been on-going since the turn of the century with the earliest studies focusing on the development of different flax types for farming. Now recognized as one of nature’s superfoods, flax has been the subject of thousands of clinical trials. Few foods or food ingredients have been studied to the same extent.

    Our database will provide you with the most current and relevant research being published on flax. We have not “cherry-picked” our publications. This flax research site is comprehensive and will provide you with unbiased comments to help you understand the findings of the results.

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