Key Findings:
Lignan intake associated with oestrogen receptor (ER) and progesterone receptor (PR) was assessed among 51,823 postmenopausal women in the Swedish Mammography Cohort. Breast cancer risk was evaluated as related to food frequency questionnaire-based estimated lignan intake. A significant inverse association between lignan intake and overall breast cancer risk, especially among postmenopausal hormone users was reported. Findings showed a lack of association among overweight women which may be due to the relatively high circulating oestrogen levels from PMH use having a stronger effect than the endogenous oestrogens formed in peripheral tissues. Lignan estimates were not highly correlated with plasma ENL. Further studies need to be undertaken with circulating level of oestrogens taken into consideration.
ABSTRACT:
Among the 51,823 postmenopausal women in the Swedish Mammography Cohort, we investigated breast cancer risk in relation to the FFQ-based estimated lignan intake by oestrogen receptor (ER) and progesterone receptor (PR) subtypes. A significant 17% risk reduction for breast cancer overall in the high lignan quartile was observed, especially among PMH user (P for interaction < 0.010), but no heterogeneity across ER/PR subtypes. (Authors abstract)
This is a free article, click below to view:
Link to Full Text