Associations of dietary linoleic acid and alpha linolenic acid intake with cardiovascular, cancer and all-cause mortalities in patients with diabetes: NHANES 1999-2008

Objective: To investigate the association between the dietary intake of linoleic acid (LA) and
alpha linolenic acid (ALA) with mortality outcomes in patients with diabetes. Participants: 3,112
U.S. adults aged≥20 years. Setting: Basic information was collected at baseline of the National
Health and Nutrition Examination Survey (NHANES). Serum CRP (mg/dL), total protein (g/L),
waist circumference (cm), fasting blood glucose (mmol/L), white blood cell count, serum LDL-C,
and serum HDL-C were also measured. Daily diets were also recorded using a 24-hour dietary
review to produce the individuals’ intake of LA and ALA. The association between tertiles of LA
and ALA intake with mortality was analyzed by weighted Cox models adjusted for the mainconfounders. Main outcome measures: The study included 3,112 adults with diabetes from the
National Health and Nutrition Examination Survey (NHANES) from 1999 to 2008. Death
outcomes were ascertained by linkage to the database records through 31 December 2015.
Results: Subjects with a high intake of LA (T3) had 17% [hazard ratio (HR) 0.83, 95% CI 0.70 to
0.99) and 48% (HR=0.52, 0.35 to 0.80)] reductions in all-cause mortality and cardiovascular
mortality, respectively, compared with subjects with lowest intake (T1). Similar results were
observed for ALA, HR of cardiovascular mortality was 0.55 (0.38 to 0.81) and for all-cause
mortality was 0.85 (0.69 to 1.04) comparing the highest to lowest intake tertiles.
Conclusion: Higher intakes of LA and ALA were inversely associated with CVD and all-cause
deaths in patients with diabetes. Proper dietary intakes of LA and ALA could contribute to the
cardiovascular health and the long-term survival of patients with diabetes.