J Hum Hypertens. , 2022., Mar;36(3):289-298. doi: 10.1038/s41371-021-00520-9.

Effect of essential fatty acid blend on circadian variations of ambulatory blood pressure in patients

Bhardwaj K Verma N Trivedi R Bhardwaj S.


Flaxseed oil is an excellent source of alpha-linolenic acid ALA known for its antihypertensive action. Flaxseed oil is unstable and its dose is not achievable in our conventional diet hence blending of natural flaxseed oil with palm oil, containing high flavonoids may be a better strategy, to stabilize the blend and provide proper balance of essential fatty acids and potential antioxidant effects. Aim of this study was to access the effect of blended flaxseed oil on 24 h 7-day circadian variations of blood pressure in subjects with essential hypertension. Assessment of CHAT (circadian hyper amplitude tension) using ABPM is the best marker for cardiovascular function. We registered 50 subjects with CAD (Group 1) and 50 subjects with Essential hypertension HT (Group 2) and 52 control subjects with CAD/Hypertension. Group 1 and 2 participant was supplemented with blended flaxseed oil (BFO) (30 ml/day) for the period of 24 weeks, while control group administered available oils sunflower in identical containers, for a follow-up period of 24 weeks. Twenty four hour seven days continuous ambulatory blood pressure monitoring was done initially and after six months of BFO supplementation. There were significant changes noted in lipid profile along with Ambulatory blood pressure parameters like MESOR, ACROPHASE, Hyperbaric Indexes, and CHAT. Circadian hyper amplitude tension (CHAT) incidence decreased after BFO supplementation. Study results suggest that blended flaxseed oil administration can be a potent natural vegetarian antihypertensive supplement which helps in synchronization of cardiac rhythms, and can be used as a preventive treatment of hypertension and as effective vegetarian source of maintaining Omega 3 and omega 6 ratios of essential fatty acids in the body.

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Key Points

In this study, the beneficial role of long term blended flaxseed oil (BFO) direct supplementation on Coronary Artery Disease subjects and Essential Hypertension was examined. The study group (group A, group B, n = 100) was supplemented with 30 ml/day BFO (blend of cold pressed food grade flaxseed oil containing high lignans and flavanoids + physically refined palm oil in 3:4 ratio, on the basis of pre nutritional information and recommendations) for the period of 24 weeks, (blended oil was used as only oil in their diet; two tea spoons as salad dressing and gravy dressing and one time grilling). 30 ml of flaxseed oil Blend contain 7.7 g of Omega 3 (ALA) 4 g of omega 6 and 7.9 g of Omega 9. The results showed  significant changes in 24 h 7 day MESOR of Systolic and Diastolic Blood pressure before and after 6 month of BFO supplementation. The study indicated that flaxseed oil could also improve the biological clock in some way which can ultimately synchronize  cardiac rhythms. In context to Blood Pressure Rhythms mechanisms include: FSO more ALA than whole flaxseed, secondly optimized ratio in BFO have more oxidative stability than flaxseed oil alone and have required amount of ALA as per guidelines of AHA, it also contain moderate amount of lignans which act as a natural antioxidant in oil. Third BFO has a beneficial  effect in improving circadian rhythms of blood pressure and cardiovascular system. The data suggests a protective role of BFO in synchronization of impaired circadian pattern of blood pressure and autonomic regulation of cardiovascular system in subjects with coronary artery disease and essential hypertension.