Key Findings
The results of this nested case control study found that increases in fasting whole blood n6 PUFA (ARA and di-homo gamma linolenic acid, DGLA) and n3 PUFA (ALA, EPA, and DHA) were associated with an increased risk of diabetes. The findings for n3 fatty acids contradict most published research and because of this, the data requires further assessment.
ABSTRACT
Objective was to determine the association of fasting whole blood fatty acid concentrations with incidence of type 2 diabetes in adults. A nested case control study of 187 subjects from a cohort of men and women aged 55 to 85 years from the Hunter Region, New South Wales, Australia. Fasting whole blood fatty acids were measured using gas chromatography and incidence of type 2 diabetes was ascertained by self reported questionnaire at the study follow up. After adjustment for potential confounding variables, positive associations with type 2 diabetes were seen for dihomo gamma linolenic acid. Lignoceric acid (C24:0) is significantly associated with lower type 2 diabetes risk. These data suggest that higher fasting whole blood concentrations of omega 6 polyunsaturated fatty acids as well as omega 3 polyunsaturated fatty acid are associated with an increased risk of diabetes, whereas increased fasting whole blood concentrations of lignoceric acid is inversely associated with diabetes risk. (Authors abstract)
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