Key Findings
Flaxseed supplementation (30 g) of only 12 weeks resulted in the reduction of biomarkers of inflammation, endothelial dysfunction, oxidative stress, and thrombosis in Chinese men with symptoms of metabolic syndrome. And flaxseed reduced n 6 to n 3 ratio which is correlated to decreases in risk for cardiovascular diseases and diabetes. No effects of flaxseed supplementation were noted for all measured cardio metabolic biomarkers which may be due to the short duration of the diet.
ABSTRACT
We investigated effects of ground whole flaxseed supplementation on erythrocyte polyunsaturated fatty acids (PUFAs) and serum biomarkers of inflammation, endothelial dysfunction, oxidative stress, and thrombosis in Chinese with risk factors of metabolic syndrome (MetS). This study was a secondary analysis of a 12 week, randomized, parallel group trial in participants screened for MetS. The analysis included only those with 2 or more components of MetS before receiving either lifestyle counseling (LC, n 90) or LC plus 30 g per day flaxseed supplementation (LCF, n 83). Compared to the LC group, those in the LCF group experienced significant increases in total erythrocyte n 3 PUFAs, alpha linolenic acid, eicosapentenoic acid, and docosapentenoic acid, while total n 6 PUFAs and n 6 ton 3 ratio decreased. Arachidonic acid increased significantly in the LC group, and serum high sensitivity C reactive protein, interleukin, soluble intracellular adhesion molecular 1, E selectin, and plasminogen activator inhibitor 1 declined significantly in both groups, but no between group differences were observed. There was no significant change in serum interleukin 6, tumor necrosis factor a, soluble vascular adhesion molecular 1, monocyte chemo attractant protein 1, and oxidized low density lipoprotein in either group. These data suggest that flaxseed supplementation increases erythrocyte n 3 PUFAs, decreases n 6 PUFAs and n 6 to n 3 ratio in participants with risk factors of MetS, but has no additional benefits beyond the lifestyle consulting for the multiple biomarkers tested in the current study. (Authors abstract)